Vancouver, BC, Canada


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NORS4002 for treatment of Sinusitis


Sinusisitis or rhinosinsitis is an inflammation of the sinuses that causes symptoms such as plugged nose, thick nasal mucosa or pain in the face to fever and headaches. Infectious causes for sinusitis can be of bacterial, viral or even fungal origin. Typical causative microbes are rhinovirus, coronavirus, influenza and adeno viruses or if the infection is of bacterial origin, the most common two causative agents are Streptococcus pneumoniae and Haemophilus influenzae.


Chronic Rhinosinsitis affects 12% of the American population below the age of 45 years. Current therapies include antimicrobials, corticosteroids, decongestants, antihistamines, mast cell stabilizers, antileukotrienes, nasal douching, immunotherapy and reduction of environmental factors. When sinusitis is refractory to conventional therapy, functional endoscopic sinus surgery (FESS) has a 76% success rate to alleviate symptoms over a 1-3 year follow-up period.


The SaNOtize team believes that NORS may be especially effective as a nasal lavage for treating sinusitis regardless of infectious microbial cause. In vitro studies have shown the effectiveness of NO and NO delivered through NORS against many strains of bacteria, viruses and fungi associated with sinusitis.